MOIPs have received growing attention from both policy and academia, and several countries and regions are beginning to implement them (Edler & Fagerberg, 2017). However, MOIPs have also been criticised for different reasons. Critics argue that MOIPs can be too top-down (Henderson et al., 2023) and that by narrowing the scope, there is a risk of leaving out alternatives or focusing on the wrong missions (Wøien Meijer et al., 2022), which eventually could risk harming the overall goal, e.g., climate neutrality. Furthermore, it is uncertain what tools are necessary for implementing MOIPs (Mazzucato, 2018), as most societal challenges that missions try to address are so-called “wicked” problems (Boon & Edler, 2018). Wicked problems tend to be highly complex, difficult to solve, involve numerous stakeholders with varying and even opposing interests, require action at different institutional levels, and no single solution or approach can be identified (Rittel & Webber, 1973; Elia & Margherita, 2018). Another key critique relates to the lack of geographical focus of MOIPs despite being developed and deployed at different territorial levels (e.g., Wanzenböck & Frenken, 2020). Scholars have long argued that applying one-size-fits-all policies to innovation efforts tends not to be feasible and risks damaging regions by disregarding existing regional specificities and capacities (Tödtling & Trippl, 2005). This argument has also been raised more specifically about MOIPs, where some scholars have questioned whether sufficient geographical knowledge is considered (e.g., Coenen et al., 2015). Scholars have, among others, feared that especially structurally weaker regions could risk suffering under EU and nationally mandated MOIPs (Cappellano et al., 2023). It is argued that today's move towards adopting MOIPs could be scrutinised (Brown, 2021), e.g., due to the lack of empirical evidence (Bloom et al., 2019). However, how are MOIPs being implemented at different territorial levels today? The following sections will shed some light on this question.